Author

N. Sinclair

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

A. Husain· 1 shared A. J. Klingelhutz· 1 shared E. A. Sander· 1 shared E. Schwalbe· 1 shared H. Davies· 1 shared J. A. Ankrum· 1 shared J. Coxhead· 1 shared J. Herrmann· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. Husain

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Author profile →

2 papers

Recent·Most cited

Native Adiponectin Plays a Role in the Adipocyte Mediated Conversion of Fibroblasts to Myofibroblasts

M. Y. El-Hattab, N. Sinclair, J. N. Liszewski, M. V. Schhrodt, J. Herrmann, A. J. Klingelhutz, E. A. Sander, J. A. Ankrum

This study identifies adiponectin as a key adipokine secreted by mature adipocytes that induces fibroblast-to-myofibroblast conversion through a TGF-β1-independent pathway.

bioRxiv · Dec 23, 2022Bioengineering

Epigenetic dysregulation underpins tumorigenesis in a cutaneous tumor syndrome.

H. Davies, K. Hodgson, E. Schwalbe, J. Coxhead, N. Sinclair, X. Zou, S. Cockell, A. Husain, S. Nik-Zainal, N. Rajan

The paper identifies epigenetic mutations as drivers of tumorigenesis in CYLD cutaneous syndrome, revealing intra-tumor heterogeneity and metastatic potential.

bioRxiv · Jul 1, 2019 · PreprintCancer Biology