H. Davies

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

PerTurboID: A targeted in situ method to measure changes in a local protein environment reveals the impact of kinase deletion on cytoadhesion in malaria causing parasites

PerTurboID measures changes in local protein environments caused by kinase deletion in malaria parasites, revealing FIKK4.1's role in regulating PfEMP1 surface levels.

Hearables: Feasibility of Recording Cardiac Rhythms from Single Ear Locations

This study demonstrates that hearables can record cardiac rhythms from a single ear, producing signals similar to Lead I ECG and robust to real-world noise.

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer

This study establishes a canine mammary tumor organoid biobank to model human breast cancer, showing genetic and phenotypic conservation and utility for drug testing and CRISPR screening.

PfHDAC1 is an essential regulator of parasite asexual growth with its altered genomic occupancy and activity associated with artemisinin drug resistance in Plasmodium falciparum

This study identifies PfHDAC1 as a critical regulator of Plasmodium falciparum growth and drug resistance, showing its activity and genomic occupancy change with artemisinin exposure.

Comprehensive cancer-oriented biobanking resource of human samples for studies of post-zygotic genetic variation involved in cancer predisposition

This paper describes a biobanking resource collecting human samples for studying post-zygotic genetic variation in cancer predisposition, including 23,226 samples from 1,711 patients and controls.

The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 Beta (B.1.351) and other variants of concern in preclinical studies.

Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA Vaccination

The paper compares antibody reactivity patterns between natural SARS-CoV-2 infection and mRNA vaccination, finding that vaccination induces stronger and broader antibody responses, including cross-reactivity against SARS antigens.

Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein

This study shows that SARS-CoV-2 spike glycoprotein does not directly interact with human basigin (CD147), challenging its role as a co-receptor for viral entry.

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

This study characterizes the structure, conformation, and glycosylation of the SARS-CoV-2 spike protein expressed by the ChAdOx1 nCoV-19/AZD1222 vaccine, confirming its native-like properties.

GDV1 C-terminal truncation of 39 amino acids disrupts sexual commitment in Plasmodium falciparum

This study identifies a C-terminal truncation mutation in GDV1 that disrupts sexual commitment in Plasmodium falciparum by destabilizing the protein, despite normal nuclear import and HP1 interaction.

Gliding motility of Plasmodium merozoites

This study shows Plasmodium merozoites can perform gliding motility, a previously unobserved movement essential for translocation across host cells before invasion.

Analysis of SARS-CoV-2 Antibodies in COVID-19 Convalescent Blood using a Coronavirus Antigen Microarray

This paper validates a coronavirus antigen microarray to distinguish SARS-CoV-2 convalescent blood from pre-pandemic controls, showing improved discrimination with spike and nucleoprotein antigens.

Analysis of Serologic Cross-Reactivity Between Common Human Coronaviruses and SARS-CoV-2 Using Coronavirus Antigen Microarray

The paper develops a coronavirus antigen microarray to study serologic cross-reactivity between common human coronaviruses and SARS-CoV-2, finding high IgG reactivity to common coronaviruses and low reactivity to SARS-CoV-2 with some cross-reactivity to conserved antigens.

Immune cells lacking Y chromosome have widespread dysregulation of autosomal genes

The paper examines immune cells with mosaic loss of the Y chromosome, finding widespread dysregulation of autosomal genes and linking this to immune dysfunction and disease.

Epigenetic dysregulation underpins tumorigenesis in a cutaneous tumor syndrome.

The paper identifies epigenetic mutations as drivers of tumorigenesis in CYLD cutaneous syndrome, revealing intra-tumor heterogeneity and metastatic potential.

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

The paper shows PMDs are hypervariable in breast cancer and drive CGI hypermethylation, but do not significantly repress cancer genes.