Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast Cancers
Diego A. Pedroza, Xueying Yuan, Fengshuo Liu, Hilda L. Chan, C. Zhang, William Bowie, Alex J. Smith, Sebastian J. Calderon, Nadia Lieu, Weiguo Wu, Paul Porter, Poonam Sarkar, Na Zhao, Constanze V. Oehler, Ondrej Peller, , Jeffrey M. Rosen
The paper shows that combining anti-CSF-1R therapy with chemotherapy and anti-PD-1 improves immune response in metastatic TNBC by reducing macrophages and increasing T/B cell infiltration.
Nature Communications · Jan 3, 2026Peer-reviewedCancer Biology