A naturally occurring Tat R52W variant in brain-derived HIV attenuates transcription and may contribute to reservoir persistence
Hongjie Chen, Nan Jiang, Yuyang Tang, Antoine Chaillon, Sara Gianella Weibel, David M. Margolis, Venkat R. Chirasani, Guochun Jiang
This study identifies an HIV-1 Tat variant (R52W) that reduces transcriptional activity, potentially contributing to viral persistence during ART.
bioRxiv · Sep 23, 2026 · PreprintMicrobiology