Author

Hongjie Chen

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Antoine ChailloniD· 2 shared David M. MargolisiD· 2 shared Guochun JiangiD· 2 shared Yuyang Tang· 2 shared Ciniso Sylvester ShabanguiD· 1 shared Edward P. BrowneiD· 1 shared Jacob B Lovins· 1 shared Manickam AshokkumariD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMicrobiology

Antoine ChaillonORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 23, 2026

A naturally occurring Tat R52W variant in brain-derived HIV attenuates transcription and may contribute to reservoir persistence

Hongjie Chen, Nan Jiang, Yuyang Tang…·Guochun Jiang

This study identifies an HIV-1 Tat variant (R52W) that reduces transcriptional activity, potentially contributing to viral persistence during ART.

DOI 10.64898/2026.09.22.753475

humanDNA methylation

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 10, 2026

✦ In-depth digest

SPP1+ Microglia Are Associated with Neuroimmune Rewiring and Glutamatergic Neuronal Injury in ART-Suppressed People Living with HIV

Ciniso Sylvester Shabangu, Hongjie Chen, Manickam Ashokkumar…·Guochun Jiang

In ART-suppressed human brain, an SPP1+ activated microglial subset holds most detected HIV RNA and shows chronic interferon-I and MHC-I signatures, alongside complement signaling and neuronal loss.

DOI 10.64898/2026.09.04.749241

𝕏 PostBluesky