DCAF: Unifying Data Validity, Evaluation Validity and Predictive Modeling for Single-cell Perturbation Simulation
Tianyi Xia, Lei Cao, Nanning Chen, Haiyang Hou, Changhao Gong, Huan Zhang, Hua Qin, Luni Hu, Di Wang, Qingsong Li, Yong Zhang, Shuangsang Fang, Yuxiang Li
DCAF improves single-cell perturbation simulation by addressing data, evaluation, and model validity, outperforming baselines in generalization and recapitulating regulatory heterogeneity in mouse brain.
bioRxiv · Oct 31, 2026 · PreprintBioinformatics