Huan Zhang

DCAF improves single-cell perturbation simulation by addressing data, evaluation, and model validity, outperforming baselines in generalization and recapitulating regulatory heterogeneity in mouse brain.

This study investigates VPS34 activation in pulmonary arterial vascular smooth muscle cells in pulmonary hypertension, finding it drives proliferation and fibrotic remodeling, and shows SAR405 inhibition reduces disease progression.

This study designs DNA condensates that control their interaction with cell membranes, showing that internalization depends on a balance between adhesion and fluidity, not just affinity.

This study analyzes the genetic diversity of the deep sea, linking protein structures to genetic variants and identifying biotechnologically relevant features.

This study identifies Brucella PrpA as a protein that activates the Tpl2-ERK pathway to induce IL-10 secretion in macrophages, promoting chronic infection and suggesting the prpA mutant as a potential vaccine.

This paper introduces a reconfigurable DNA memory architecture that enables hierarchical data management through programmable phase transitions, achieving high storage density and stability.

The paper reports the observation of developing oocytes in a post-spawning Japanese eel in captivity, suggesting possible multiple spawning potential.