David Gate

SpaMosaic integrates spatial multi-omics data using contrastive learning and graph neural networks, improving spatial domain identification and missing modality imputation across diverse datasets.

This paper introduces a mid-infrared photothermal mesoscope with millimeter-scale field of view and sub-micron resolution, enabling in vivo chemical imaging and Alzheimer's disease biomarker detection.

This study shows that anti-CD49d antibody treatment reduces age-related inflammatory responses and CD8 T cell cytotoxicity after traumatic brain injury in mice.

This study shows that neuronal ACE1 knockout in mice causes hippocampal RAS dysregulation and vascular loss without affecting motor skills.

The paper analyzes single-nucleus transcriptomes from brain and choroid plexus tissues of COVID-19 and influenza patients, identifying broad transcriptional dysregulation in multiple cell types and linking these changes to neurological symptoms.

VINE-seq yields 143,793 single-nucleus transcriptomes of human brain vascular and perivascular cells; 30 of the top 45 Alzheimer's GWAS genes are expressed there, many microglial in mice.

Profiling 2,925 plasma proteins in 4,331 people aged 18-95 reveals non-linear aging: protein waves crest at 34, 60 and 78 years, later waves overlapping disease proteomes.