Neuropeptide Y4 receptor activation delays autoimmune diabetes by reprogramming β-cell stress and immune tolerance
Naila Haq, Klaudia Toczyska, Anowara Islam, Oladapo Edward Olaniru, Yuxian Lei, Ming Hu, M Zhao, R Müller, Mohammed Kamran Afzal Mirza, Nick Fine, David J. Hodson, Shanta Jean Persaud, Annette Gabriele Beck‐Sickinger, James Alexander Pearson, Gavin A. Bewick
This study shows that activating the Y4R receptor protects β-cells and modulates islet immunity, delaying autoimmune diabetes in multiple models.
bioRxiv · Jul 4, 2026 · PreprintCell Biology