Shanta Jean Persaud

This study shows that activating the Y4R receptor protects β-cells and modulates islet immunity, delaying autoimmune diabetes in multiple models.

This study shows that inhibiting NAMPT reduces inflammation and beta-cell damage in T1D by blocking cytokine-mediated immune responses in mice.

This study develops a long-term primary cell-based platform called reformed islets to study mouse and human islet biology, showing they retain key physiological and functional features of native islets.

This study integrates single-cell RNA sequencing and spatial transcriptomics to map the temporal-spatial gene expression patterns during human pancreas development, identifying lineage dynamics and novel genes involved in beta cell maturation.