Autotaxin Inhibition Ameliorates HFpEF Phenotype By Reducing LPA-Mediated Systemic Inflammation And Cardiac Remodeling
Rajesh Chaudhary, Andrew Robbins, Anand P. Singh, Parisa Shabani, Tahra Kaur Luther, Afnan Alzamrooni, Rachel Lopez, Tania Maheshwari, Nicolas Collins, Scott L. Hummel, Ahmed Abdel‐Latif
This study shows autotaxin inhibition reduces LPA-mediated inflammation and cardiac remodeling in HFpEF, improving diastolic function and fibrosis in mice and showing altered lysophospholipid profiles in humans.
bioRxiv · Aug 30, 2026 · PreprintImmunology