Beyond the Final Layer: Evaluating Single-Cell Foundation Model Representations for Molecular Prediction
Ming-Ching Crystal Wen, Yiwei Lyu, Andrew Robbins
This paper evaluates the performance of intermediate layers in single-cell foundation models for cell-type and perturbation prediction, finding that some layers perform as well as final layers.
bioRxiv · Oct 12, 2026 · PreprintBioinformatics