Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice
Robert Nathaniel Helsley, Mikala M. Zelows, Victoria P. Noffsinger, Garrett Anspach, Nikitha Dharanipragada, Anna E. Mead, Isidoro Cobo, Abigail Carter, Qinglin Wu, IRINA Y. SHALAUROVA, Kai Saito, Josh M. Morganti, Scott M. Gordon, Gregory A. Graf
This study shows that reducing CPT1a in the liver lowers apoB-containing lipoproteins and cholesterol in mice, with increased clearance of these lipoproteins linked to enhanced PPAR signaling.
Arteriosclerosis Thrombosis and Vascular Biology · Jun 12, 2025Peer-reviewedPhysiology