Reduced Capsaicin-Induced Mechanical Allodynia and Neuronal Responses in the DRG in the Presence of Shp1 Overexpression
Robin Vroman, Shingo Ishihara, Spencer Fullam, Matthew J. Wood, Natalie S. Adamczyk, Nolan Lomeli, Fransiska Malfait, Anne‐Marie Malfait, Rachel E. Miller, Adrienn Markovics
This study shows that SHP-1 overexpression reduces capsaicin-induced mechanical allodynia in both male and female mice by dephosphorylating TRPV1 in DRG neurons.
bioRxiv · Jan 23, 2024 · PreprintNeuroscience