Shingo Ishihara

This study shows that repeated NGF injections into mouse knees cause multiple OA-like features without cartilage damage.

The study shows CD14 is critical for pain and inflammation in post-traumatic osteoarthritis and that blocking CD14 can reduce pain and mobility loss.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

This study shows that inhibiting Piezo2 reduces acute inflammatory and osteoarthritis knee pain in mice using FM-dyes.

This study shows that acute systemic macrophage depletion reduces pain-related behaviors in osteoarthritic mice without affecting joint damage.

This paper develops a 3D imaging workflow using clearing-enabled light sheet microscopy to map mouse knee joint innervation and demonstrates changes in nerve density after NGF injection.

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.

This study shows that SHP-1 overexpression reduces capsaicin-induced mechanical allodynia in both male and female mice by dephosphorylating TRPV1 in DRG neurons.

The paper examines nociceptor sprouting in four mouse models of knee OA, finding progressive neuroplasticity associated with joint damage across different stages of the disease.

This study identifies an aggrecan fragment that activates TLR2 on nociceptors, causing pain in osteoarthritis.

This study uses in vivo calcium imaging to show that DMM surgery increases the number of sensory neurons responding to mechanical stimuli in mice, indicating neuronal sensitization.