Identification and inhibition of the Cyclin D Rb-docking interface that drives cell division
Benjamin R. Topacio, Cecelia Fleming, Michael Charles Lanz, Mihkel Örd, Mina Memarpoor-Yazdi, Shuyuan Zhang, Shicong Xie, Jürgen Tuvikene, Aiden Weaver, Ioannis Sanidas, Norman Davey, Peter Pryciak, Julien Sage, Seth Rubin, Mardo Kõivomägi, Jan Skotheim
This study identifies a unique docking interface on cyclin D that binds Rb, a key cell cycle regulator, and shows that targeting this interface can inhibit cell proliferation.
bioRxiv · Oct 29, 2026 · PreprintBiochemistry