Michael Charles Lanz

This study identifies a unique docking interface on cyclin D that binds Rb, a key cell cycle regulator, and shows that targeting this interface can inhibit cell proliferation.

This study expands the yeast genome with non-coding DNA and finds it reduces growth rate and endogenous mRNA concentration without affecting translation.

The paper shows that cell size affects mRNA concentrations, driving proteome changes through transcriptional regulation.

This study shows that yeast cells adapt to changes in mitochondrial DNA copy number through retrograde signaling and protein dosage compensation, allowing robust growth despite mtDNA fluctuations.

This study shows that phosphorylation stabilizes Rb by promoting its dissociation from chromatin, revealing a mechanism linking chromatin association to protein degradation.

This study shows that cell enlargement drives proteome remodeling and shortens replicative lifespan in yeast, independent of known aging factors.

This study develops and validates a biophysical model showing that constant ratios of cytoplasmic and membrane protein densities regulate Escherichia coli cell geometry through proteome partitioning and ribosome content.

The paper shows that intracellular diffusion in fission yeast increases with cell size, linked to changes in proteome composition and DNA-to-cytoplasm ratio.

The paper shows genome concentration limits transcription and affects proteome composition in E. coli, with effects detectable in nutrient-rich conditions.

The paper shows that increasing cell size leads to proteome remodeling similar to starvation, driven by genome dilution in mammalian and yeast cells.

The paper challenges a model proposing that protein synthesis increases in pre-Start G1, finding that Whi5 concentration remains constant and Cln3 increase is not due to synthesis.

MaXLinker improves cross-link identification by reducing false positives and increasing sensitivity, revealing 9,319 cross-links in K562 cells.