Shuyuan Zhang

This study identifies a unique docking interface on cyclin D that binds Rb, a key cell cycle regulator, and shows that targeting this interface can inhibit cell proliferation.

This study shows that phosphorylation stabilizes Rb by promoting its dissociation from chromatin, revealing a mechanism linking chromatin association to protein degradation.

This study shows that larger cells are more resistant to ferroptosis due to higher glutathione levels and lower lipid peroxides.

This study shows that cell size autonomously regulates the G1/S transition in mammalian epidermal stem cells, independent of extracellular signals.

The paper develops human tri-lineage brain microtissues composed of neurons, astrocytes, and microglia, showing they recapitulate cell-cell interactions and pathological processes.

The paper identifies UBR5-mediated Rb degradation as a mechanism promoting G1/S transition by reducing Rb levels in early G1.

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

The paper shows that increasing cell size leads to proteome remodeling similar to starvation, driven by genome dilution in mammalian and yeast cells.