Constitutive sodium permeability in a C. elegans two-pore domain potassium channel
O. Andrini, I. Ben Soussia, P. Tardy, D. S. Walker, C. Pena-Varas, D. Ramirez, M. Gendrel, M. Mercier, S. El Mouridi, A. Leclercq-Blondel, W. Gonzalez, W. R. Schafer, M. Jospin, T. Boulin
This study identifies a unique sodium permeability in the C. elegans K2P channel UNC-58, driven by an atypical cysteine residue in its selectivity filter, highlighting the need for functional experiments to understand sequence variations in potassium channels.
bioRxiv · Jan 22, 2024 · PreprintPhysiology