ASNA-1 oxidation induced by cisplatin exposure enhances its cytotoxicity by selectively perturbing tail anchored protein targeting
D. Raj, O. Billing, A. Podraza, O. Hemmingsson, G. Kao, P. Naredi
This paper shows that cisplatin-induced oxidation of ASNA-1 disrupts tail-anchored protein targeting, leading to ER dysfunction and increased cisplatin sensitivity in C. elegans.
bioRxiv · Oct 28, 2019 · PreprintCell Biology