Cell BiologybioRxivPreprint
ASNA-1 oxidation induced by cisplatin exposure enhances its cytotoxicity by selectively perturbing tail anchored protein targeting
D. Raj, O. Billing, A. Podraza…·P. Naredi
This paper shows that cisplatin-induced oxidation of ASNA-1 disrupts tail-anchored protein targeting, leading to ER dysfunction and increased cisplatin sensitivity in C. elegans.
DOI 10.1101/821728