Structural Conservation of Insulin/IGF Signalling Axis at the Insulin Receptors Level in Drosophila and Humans
C. M. Viola, O. Frittmann, H. T. Jenkins, T. Shafi, P. De Meyts, A. M. Brzozowski
This study presents the cryoEM structure of the Drosophila insulin receptor (dmIR) complex with DILP5, showing structural homology to human IRs and dmIR-specific features.
bioRxiv · Feb 17, 2023 · PreprintBiochemistry