O. Tenaillon

Predictability shifts from local to global rules during bacterial adaptation

The study shows that short-term bacterial adaptation is predictable at the gene level, while long-term adaptation follows global statistical patterns.

Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes

The paper predicts polymorphisms in 61,157 Escherichia coli genomes using context-aware models, showing genetic context constrains amino-acid changes in 30-50% of sites.

Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1

The paper quantifies epistasis in a β-lactamase α-helix using double mutants and shows it can be explained by a non-linear two-state model.

The role of mutational spectrum in the selection against mutator alleles

This study shows that mutator susceptibility to antimutator invasions depends on mutation bias and deleterious load, revealing environmental and genetic factors influencing antimutator dynamics.

Accumulation of deleterious mutations during bacterial range expansions

This study shows that mutator bacteria accumulate deleterious mutations during range expansion, reducing their fitness, while low mutation rate strains maintain stability.