M. Ackermann

Epidemiological, Serological, and Virological Analysis of an Outbreak of Elephant Hemorrhagic Disease in Switzerland

The paper analyzes an EHD outbreak in Swiss elephants, identifying a previously undetected EEHV1A strain and highlighting the need for better antiviral strategies.

Multidimensional Analysis of the Adult Human Heart in Health and Disease using Hierarchical Phase-Contrast Tomography (HiP-CT)

This paper demonstrates HiP-CT's ability to image adult human hearts at multiple scales, revealing structural details in health and disease.

Polysaccharide breakdown products drive degradation-dispersal cycles of foraging bacteria through changes in metabolism and motility

This study shows that marine bacteria switch from polysaccharide degradation to motility when exposed to breakdown products, enabling dispersal to new nutrient sources.

Nanoscale clustering by O-antigen-Secretory Immunoglobulin-A binding limits outer membrane diffusion by encaging individual Salmonella cells

The paper shows SIgA binding to Salmonella O-antigen nanoscale crosslinks the outer membrane, leading to biased inheritance and accelerated IgA escape through phase-variation.

Mapping the blood vasculature in an intact human kidney using hierarchical phase-contrast tomography

This study maps the entire human kidney vasculature using hierarchical phase-contrast tomography, revealing structural differences in vascular architecture across kidney zones.

Interspecies interactions determine growth dynamics of biopolymer degrading populations in microbial communities.

This study investigates how consumer cells affect the growth and spatial distribution of biopolymer-degrading microbes in marine communities, revealing their impact on enzyme production and community dynamics.

Changes in interactions over ecological time scales influence single cell growth dynamics in a metabolically coupled marine microbial community

The paper studies how dynamic interactions between two marine microbes change over time, showing initial cooperation followed by competition as their environment shifts.

Effects of interspecies interactions on marine community ecosystem function

This study shows that interactions between microbial species affect chitin degradation rates through changes in chitinase expression, challenging the idea of unidirectional trophic cascades in microbial communities.

Preparation of large biological samples for high-resolution, hierarchical, multi-modal imaging

This paper describes a protocol for preparing large biological samples for high-resolution X-ray microtomography, improving contrast and reducing motion and bubble formation.

Extracellular appendages govern spatial dynamics and growth of Caulobacter crescentus on a prevalent biopolymer

This study shows that extracellular appendages in Caulobacter crescentus influence spatial dynamics and growth on xylan by affecting cell density and competition.

Intercellular collectivity is governed by enzyme secretion strategies in marine polysaccharide degrading bacteria

The paper studies how enzyme secretion strategies in marine bacteria affect their aggregative behaviors and intercellular interactions during polysaccharide degradation.

3D virtual Histopathology of Cardiac Tissue from Covid-19 Patients based on Phase-Contrast X-ray Tomography

This study uses phase-contrast x-ray tomography to analyze 3D cardiac tissue structure from Covid-19 patients, revealing distinct vascular changes compared to other viral myocarditides.

A multiscale X-ray phase-contrast tomography dataset of whole human left lung

The paper presents a high-resolution X-ray tomography dataset of a whole human left lung, capturing multiscale anatomical details from macroscopic to microscopic levels.

Ceylon cinnamon and its major compound Cinnamaldehyde can limit overshooting inflammatory signaling and angiogenesis in vitro: implications for COVID-19 treatment

This study shows that Ceylon cinnamon and cinnamaldehyde reduce inflammatory signaling and angiogenesis in vitro, potentially allowing lower dexamethasone doses for COVID-19 treatment.

Microbiota-derived metabolites inhibit Salmonella virulent subpopulation development by acting on single-cell behaviors

This study shows microbiota-derived short-chain fatty acids reduce Salmonella virulent subpopulation frequency by slowing their growth, not by repressing SPI-1 expression at the single-cell level.

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

This paper introduces HiP-CT, a technique for high-resolution 3D imaging of intact human organs, and demonstrates its application to study structural details of organs and their functional units.

A distinct growth physiology enhances bacterial growth under rapid nutrient fluctuations

This study shows that E. coli grown in fluctuating nutrient environments has a distinct physiology that reduces growth rate loss compared to steady environments with the same average nutrient concentration.

STREPTOCOCCUS PNEUMONIAE SEROTYPE 22F INFECTION IN RESPIRATORY SYNCYTIAL VIRUS INFECTED NEONATAL LAMBS ENHANCES MORBIDITY

This study shows that RSV and S. pneumoniae 22F co-infection in neonatal lambs increases disease severity through immune response changes, not bacterial load.

Clinical extended-spectrum beta-lactamase antibiotic resistance plasmids have diverse transfer rates and can spread in the absence of antibiotic selection

This study quantifies the conjugative transfer dynamics of ESBL plasmids in vitro and in vivo, showing variation in transfer efficiency and potential for predicting plasmid spread.

Understanding the evolution of interspecies interactions in microbial communities

The paper reviews how evolution shapes microbial community interactions and proposes a model linking spatial structure to the evolution of interspecies interactions.

Emergent microscale gradients give rise to metabolic cross-feeding and antibiotic tolerance in clonal bacterial populations

This study shows that microscale metabolic gradients in bacterial populations enable cross-feeding and antibiotic tolerance through spatially structured metabolic interactions.

Stochastic gene expression influences the selection of antibiotic resistance mutations

This study shows stochastic gene expression affects the selection of antibiotic resistance mutations, with regulatory and structural mutations providing different resistance mechanisms.

Individual- versus group-optimality in the production of secreted bacterial compounds

The paper shows that for shared compounds with saturating benefits, division of labor evolves when production costs diminish with higher output, as demonstrated through mathematical modeling and experimental testing with pyoverdine.

Genomic analysis of fast expanding bacteria reveals new molecular adaptive mechanisms

This study shows artificial selection can counteract the negative effects of bacterial range expansion by increasing expansion speed through loss of function mutations.

Prolonged lag time results in small colony variants and reflects a sub-population of persisters in vivo

The paper shows that small colony variants in Staphylococcus aureus result from prolonged lag times, not mutations, and are linked to antibiotic tolerance and persisters in vivo.

Effective polyploidy causes phenotypic delay and influences bacterial evolvability

This study shows antibiotic resistance mutations in E. coli have a 3-4 generation phenotypic delay due to effective polyploidy, impacting mutation rate estimation and evolutionary adaptation.

Local interactions lead to spatially correlated gene expression levels in bacterial groups.

The paper shows spatial correlations in gene expression among Escherichia coli cells due to local interactions and shared microenvironment.

Magnitude and mechanism of siderophore-mediated competition in bacterial interactions

The paper investigates siderophore-mediated competition in bacterial interactions, finding that competitive inhibition can be more beneficial than cooperation in iron-limited environments.

Accumulation of deleterious mutations during bacterial range expansions

This study shows that mutator bacteria accumulate deleterious mutations during range expansion, reducing their fitness, while low mutation rate strains maintain stability.