M. Petitjean

Mannose Supplementation Curbs Liver Steatosis and Fibrosis in Murine MASH by Inhibiting Fructose Metabolism

This study shows that mannose reduces liver steatosis and fibrosis in MASH by inhibiting fructose metabolism, offering a potential therapeutic approach.

Inter-phylum circulation of a beta-lactamase - encoding gene: a rare but observable event

The paper reports the first inter-phylum transfer of an ESBL-encoding gene, blaMUN-1, between Bacteroidota and Pseudomonadota, highlighting rare but possible horizontal gene transfer events.

SHORT-TERM CALORIC RESTRICTION IN MICE PROMOTES RESOLUTION OF ATHEROSCLEROSIS, WHILE WEIGHT REGAIN ACCELERATES ITS PROGRESSION

This study shows that short-term caloric restriction in mice reduces atherosclerosis by promoting Fcgr4+ macrophages, while weight regain accelerates plaque progression by eliminating these cells and reprogramming immune progenitors.

ResFinderFG v2.0: a database of antibiotic resistance genes obtained by functional metagenomics

ResFinderFG v2.0 is a database of antibiotic resistance genes from functional metagenomics, improving resistome description by detecting ARGs not found in conventional databases.

Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes

The paper predicts polymorphisms in 61,157 Escherichia coli genomes using context-aware models, showing genetic context constrains amino-acid changes in 30-50% of sites.

Phylum barrier and Escherichia coli intra-species phylogeny drive the acquisition of resistome in E. coli

This study characterizes the resistome in 70,301 E. coli genomes, showing that phylogroup lineage and phylum barriers drive antibiotic resistance gene acquisition.

The rise and the fall of a Pseudomonas aeruginosa epidemic lineage in a hospital

This study tracks the rise and fall of a Pseudomonas aeruginosa epidemic lineage in a hospital, linking its persistence to genomic adaptations and its decline to genome size reduction and infection control measures.