Author

Olivier Cahn

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrian YangiD· 2 shared Florian T. MerkleiD· 2 shared Hsiao‐Jou Cortina CheniD· 2 shared Iman D. MaliiD· 2 shared John C. MarioniiD· 2 shared Simone MazzaferroiD· 2 shared Bavesh Jawahar· 1 shared Chad A. Cowan· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Andrian YangORCID

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2 papers

Recent·Most cited

GLP-1R agonists activate human hypothalamic neurons

Simone Mazzaferro, Hsiao‐Jou Cortina Chen, Olivier Cahn, Andrian Yang, Dmytro Shepilov, Eugene Seah, Jiahui Chen, Bavesh Jawahar, Constanza Alcaino, Viviana Macarelli, Iman D. Mali, John A. Tadross, Fiona Mary Gribble, Frank M. Reimann, John C. Marioni, Florian T. Merkle

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

bioRxiv · Apr 2, 2024 · PreprintNeuroscience

Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss

Hsiao‐Jou Cortina Chen, Andrian Yang, Simone Mazzaferro, Iman D. Mali, Olivier Cahn, Katherine A. Kentistou, Christine Rowley, Natasha M. Stewart, Jun Wen Eugene Seah, Venkat Pisupati, Peter Kirwan, Sanya Aggarwal, Takafumi Toyohara, Mary H.C. Florido, Chad A. Cowan, , Florian T. Merkle

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

bioRxiv · Jul 18, 2023 · PreprintNeuroscience