Viviana Macarelli

The paper identifies ciliary proteins in human hypothalamic neurons and finds new therapeutic targets for obesity, including LPAR1, which mediates ciliary shortening.

The paper identifies a short peptide sequence that efficiently targets transmembrane proteins to primary cilia across cell types and develops an image analysis pipeline for automated cilia measurement.

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

This study shows metformin can slow neurodegeneration features in mice, even in metabolically healthy individuals, by acting directly in the brain.