Epigenetic Silencing of Carotid Body TRPM7 Attenuates Hypertension in Obese Mice
Mi-Kyung Shin, Arijit Roy, Omkar Padel, Samhita Gudapati, James S.K. Sham, Wan-Yee Tang, Vsevolod Y. Polotsky
This study shows that reversing DNA methylation at the Trpm7 promoter in carotid bodies of obese mice reduces hypertension by decreasing Trpm7 expression and nerve activity.
bioRxiv · Mar 7, 2026 · PreprintPhysiology