ssDNA hand-off from RPA to Polθ drives microhomology-mediated end-joining
Martha Longley, Hyunjee Lee, Owen Eby, Bhasker Dharavath, Yufan Wu, Abhilash Jayaraj, Felix Steinruecke, Haribabu Arthanari, Ralph Scully, Lucas Farnung, Joseph J. Loparo, Johannes Walter
The paper reveals that RPA activates TMEJ by facilitating ssDNA hand-off to Polθ, which initiates microhomology search for DNA repair.
bioRxiv · Oct 28, 2026 · PreprintBiochemistry