Haribabu Arthanari

The paper reveals that RPA activates TMEJ by facilitating ssDNA hand-off to Polθ, which initiates microhomology search for DNA repair.

This study shows phosphorylation of IGF2BP1 and IGF2BP3 at a conserved serine acts as a configurational switch, altering their RNA binding domain arrangements and affecting mRNA regulation.

This study investigates how conformational changes in TcmN aromatase/cyclase regulate substrate binding and product release during polyketide biosynthesis.

The paper shows FoxP3 forms head-to-head dimers and stabilizes multimerization on microsatellites in Tregs, revealing a dual DNA-binding mode.

The paper identifies a novel composite motif in CLMB that enables multimeric dephosphorylation by calcineurin, influencing its membrane localization and signaling.

This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.

This study investigates the DNA-binding mechanism of BCL11A, revealing the role of ZnF6 in repression of {gamma}-globin gene expression and its implications for therapeutic design.

This paper identifies a multi-layered mechanism by which Aire forms transcriptional condensates on enhancers through coordinated interactions between its CARD, PHD1, and CTT domains.

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

AdaptiveFlow enables large-scale virtual screening of 69 billion molecules to discover validated FSP1 inhibitors, improving efficiency and scalability in drug discovery.

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.