Author

P. Ashcroft

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Bonhoeffer· 2 shared L. Sun· 1 shared M. Ackermann· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersEvolutionary Biology

S. Bonhoeffer

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2 papers

Recent·Most cited

Constrained optimisation of divisional load in hierarchically-organised tissues during homeostasis

P. Ashcroft, S. Bonhoeffer

The paper develops a mathematical model to optimise divisional load in hierarchical tissues during homeostasis, finding that binary division trees with non-self-renewing progenitors minimise mutation risk.

bioRxiv · Oct 7, 2021 · PreprintEvolutionary Biology

Stochastic gene expression influences the selection of antibiotic resistance mutations

L. Sun, P. Ashcroft, M. Ackermann, S. Bonhoeffer

This study shows stochastic gene expression affects the selection of antibiotic resistance mutations, with regulatory and structural mutations providing different resistance mechanisms.

bioRxiv · Aug 6, 2019Evolutionary Biology