An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunity
G. Ghislat, A. S. Cheema, E. Baudoin, C. Verthuy, P. Ballester, K. Crozat, N. Attaf, C. Dong, P. Milpied, B. Malissen, N. Auphan-Anezin, T.-P. V. Manh, M. Dalod, T. Lawrence
This study identifies the NF-κB/IRF1 axis as critical for cDC1 maturation and anti-tumor immunity, showing its role in CD8+ T cell activation and tumor control.
bioRxiv · Dec 28, 2020Immunology