C. Dong

Construction of a breast cancer predictive nomogram based on diverse cell death methods and reveal tumor microenvironment characterization

The paper develops a breast cancer prognostic model and nomogram using LASSO Cox analysis and evaluates tumor microenvironment and drug sensitivity differences between subgroups.

Peripheral B Lymphocyte Serves as A Reservoir for The Persistently Covert Infection of Mandarinfish Siniperca chuatsi Ranavirus

This study identifies peripheral B lymphocytes as a viral reservoir for persistent and covert Mandarinfish Ranavirus (MRV) infection, revealing a unique reactivation mechanism distinct from other ranaviruses.

Decellularization of Rat Gracilis Muscle Flap as a Potential Scaffold For Skeletal Muscle Composite Allotransplantation

This study decellularizes rat gracilis muscle flaps to create scaffolds for skeletal muscle transplantation, finding that longer decellularization reduces DNA content without compromising microcirculation.

The immune profile of circulating autoreactive CD4 T cells is imprinted through tissue activation during autoimmune liver diseases

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

AAV eluting lenses for single-step targeted expression of genetically- encoded activity sensors for in vivo microendoscopic calcium imaging

This paper develops AAV-eluting lenses for single-step targeted expression of GCaMP in vivo, improving alignment and surgical flexibility for microendoscopic calcium imaging.

Structure and evolution of Alanine/Serine Decarboxylases and the engineering of theanine production

This study solves the structures of AlaDC and SerDC, identifies key residues for activity and specificity, and shows engineered variants improve theanine production.

A syntelog-based pan-genome provides insights into rice domestication and de-domestication

This paper constructs a syntelog-based pan-genome of rice using long-read sequencing to study domestication and de-domestication, identifying introgression events and domestication genes.

New gene evolution with subcellular expression patterns detected in PacBio-sequenced genomes of Drosophila genus

The paper analyzes gene age and subcellular expression patterns in Drosophila species using PacBio sequencing, finding new genes enriched in extracellular compartments and old genes in mitochondria and plasma membrane.

Mesenchymal stromal cells and alpha-1 antitrypsin have a strong synergy in modulating inflammation and its resolution

This study shows that combining mesenchymal stromal cells and alpha-1 antitrypsin significantly improves inflammation modulation and resolution in vitro and in a mouse model.

The frequent occurrence and metabolic versatility of Marinifilaceae bacteria involved in organic matter mineralizationas a key member in global deep sea

This paper identifies Marinifilaceae bacteria as key players in deep-sea organic matter mineralization, revealing their metabolic versatility and role in carbon and nitrogen cycling.

Lineage-specific genes are clustered with allorecognition loci and respond to GxE factors regulating the switch from asexual to sexual reproduction in Neurospora

The paper identifies lineage-specific genes (LSGs) in Neurospora crassa that cluster with allorecognition loci and respond to environmental factors regulating the switch from asexual to sexual reproduction.

OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice

This study shows that TH5487, an OGG1 inhibitor, reduces allergic airway inflammation in mice by decreasing mucus production, immune cell recruitment, and proinflammatory cytokines.

Functional plasticity and recurrent cell states of malignant B cells in follicular lymphoma

This study identifies recurrent malignant B cell states in follicular lymphoma using single-cell RNA-seq and shows their functional plasticity and niche-specific localization.

Viral infection engenders bona fide and bystander lung memory B cell subsets through permissive selection

The paper identifies two distinct lung memory B cell subsets post-viral infection, showing they arise from different progenitors and are classified as virus-specific or bystander based on antigen specificity.

Genomic and experimental evidence that alternate transcription initiation of the Anaplastic Lymphoma Kinase (ALK) kinase domain does not predict single agent sensitivity to ALK inhibitors.

The paper reanalyzes ALKATI's role in melanoma using genomic and experimental methods, finding it does not predict single-agent ALK inhibitor sensitivity.

Species-specific gene duplication in Arabidopsis thaliana evolved novel phenotypic effects on morphological traits under strong positive selection

This study identifies a young gene in Arabidopsis thaliana that shows strong positive selection and contributes to morphological trait divergence through neofunctionalization.

An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunity

This study identifies the NF-κB/IRF1 axis as critical for cDC1 maturation and anti-tumor immunity, showing its role in CD8+ T cell activation and tumor control.

Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids

This study determines the atomic structure of PLEKHA7's PH domain and reveals its multivalent interaction mechanism with membrane-bound PIPs, providing insights for inhibitor design.

Effects of long-term closed environment on human saliva microbiota and salivary cytokines

This study examines how a controlled closed environment affects human saliva microbiota and cytokines, finding stable microbial communities and reduced inflammatory markers.

Biomechanical Characterization of SARS-CoV-2 Spike RBD and Human ACE2 Protein-Protein Interaction

This study quantifies the biophysical differences in SARS-CoV-2 and SARS-CoV-1 RBD-ACE2 interactions using single-molecule force spectroscopy and SMD simulations, revealing a key N-glycan interaction in SARS-CoV-2 that enhances binding affinity.

Magnetic Temporal Interference For Noninvasive, High-resolution, and Localized Deep Brain Stimulation: Concept Validation

The paper validates a concept using magnetic temporal interference to achieve noninvasive, high-resolution, and localized deep brain stimulation by exploiting low-frequency envelope stimulation from interfering high-frequency fields.

Ultra-compact Dual-band Smart NEMS Magnetoelectric Antennas for Simultaneous Wireless Energy Harvesting and Magnetic Field Sensing

This paper introduces an ultra-compact dual-band smart NEMS magnetoelectric antenna for wireless energy harvesting and magnetic field sensing in implantable medical devices.

Structural insight into outer membrane asymmetry maintenance of Gram-negative bacteria by the phospholipid transporter MlaFEDB

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs

This study examines bisubstrate analog interactions with NTMT1 to understand active site plasticity and identifies a 4-C linker analog as the most potent inhibitor.

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies

This paper designs and characterizes peptidomimetic inhibitors of NTMT1/2, showing high selectivity and cell-permeable activity.

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.

The paper identifies two prognostic cervical squamous cell carcinoma subtypes across three continents, revealing conserved molecular and immune features.

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex

The paper determines the crystal structure of the MBTD1-EPC1 complex, revealing the molecular mechanism of MBTD1 recruitment into the NuA4/TIP60 acetyltransferase complex.

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

The paper characterizes autoreactive CD4 T cells in autoimmune hepatitis patients, identifying a specific phenotype linked to disease activity and IgG response.

FB5P-seq: FACS-based 5-prime end single-cell RNAseq for integrative analysis of transcriptome and antigen receptor repertoire in B and T cells

Dissecting the first phased dikaryotic genomes of the wheat rust pathogen Puccinia triticina reveals the mechanisms of somatic exchange in nature

This study generates and analyzes the first dikaryotic phased genomes of Puccinia triticina, identifying a somatic hybrid and revealing mitotic crossover as the mechanism of parasexuality in rust pathogens.