B. Malissen

Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors

The dual character of the inhibitory functions of CD6

This study investigates CD6's dual inhibitory and costimulatory functions, showing it suppresses T cell responsiveness via its cytoplasmic domain and modulates autoimmunity through extracellular interactions.

Interferon-induced lysosomal membrane permeabilization and death cause cDC1-deserts in tumors.

This study identifies interferon-induced lysosomal membrane permeabilization and death as mechanisms causing cDC1 scarcity in tumors, suggesting therapeutic strategies to enhance anti-tumor immunity.

Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine

This study designs a pan-sarbecovirus vaccine targeting conserved epitopes and shows it induces cross-neutralizing antibodies and T-cell responses in mice and humans.

Viral infection engenders bona fide and bystander lung memory B cell subsets through permissive selection

The paper identifies two distinct lung memory B cell subsets post-viral infection, showing they arise from different progenitors and are classified as virus-specific or bystander based on antigen specificity.

Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation

This study shows that redox regulation of PTPN22 via cysteine 129 affects T cell-dependent autoimmune inflammation severity in mice.

Cellular selectivity of STING stimulation determines priming of tumor-specific T cell responses

This study shows that targeting STING in dendritic cells with cGAMP-VLP enhances tumor-specific T cell responses and synergizes with PD1 blockade for tumor eradication, while synthetic CDN causes systemic T cell activation without specific T cell differentiation.

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

This study identifies EGR2 as essential for the identity and function of alveolar macrophages in health and tissue repair.

An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunity

This study identifies the NF-κB/IRF1 axis as critical for cDC1 maturation and anti-tumor immunity, showing its role in CD8+ T cell activation and tumor control.

Migration of intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation

This study shows that cDC1 and cDC2 subsets migrate similarly in response to TLR3 stimulation, but cDC1 requires type I interferon signaling, highlighting distinct pathways in DC subset migration.