Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen specific tumor cell killing by cytotoxic T cells
A.-K. Mattes, M. Puig Gamez, E. Martin, L. Boryn, P. Baskaran, H. J. Huber, M. Schuler, J. E. Park, L. K. Swee
The paper uses a complementary CRISPR screen to identify genes regulating tumor resistance to CTL killing, revealing contrasting roles of membrane-bound and soluble ICAM-1.
bioRxiv · Aug 26, 2022Cancer Biology