M. Schuler

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

The paper identifies ABHD17B as a therapeutic target for liver fibrosis by showing its depletion inactivates hepatic stellate cells and reduces fibrosis in mice.

A phloem-localized Arabidopsis metacaspase (AtMC3) improves drought tolerance

This study shows that overexpressing AtMC3, a phloem-specific metacaspase in Arabidopsis, improves drought tolerance by enhancing vascular function and osmotic stress responses.

Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen specific tumor cell killing by cytotoxic T cells

The paper uses a complementary CRISPR screen to identify genes regulating tumor resistance to CTL killing, revealing contrasting roles of membrane-bound and soluble ICAM-1.

High-resolution epigenetic profiling identifies novel regulators of COPD in human lung fibroblasts

This study identifies novel epigenetic and transcriptomic regulators of COPD in human lung fibroblasts across disease stages.

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in an iPSC-derived air-liquid interface model

This study develops an iPSC-derived air-liquid interface model to mimic IPF-related bronchiolization and shows IPF-RC stimulation alters ATII differentiation and transcriptome profiles.

A framework for disentangling ecological mechanisms underlying the island species-area relationship

This paper introduces a framework to disentangle ecological mechanisms underlying the island species-area relationship using sampling-explicit parameters from rarefaction curves.