Binucleated cell formation and oncogene expression after particulate matter exposure is preceded by microtubule disruption, dysregulated cell cycle, prolonged mitosis, and septin binding
R. Podlipec, A. Sebastijanovic, H. Cassidy, L. Han, P. Danielsen, P. Cotar, H. Kokot, B. Korosevic Koser, A. Vencelj, L. Pirker, P. Umek, G. Hlawacek, R. Heller, D. Matallanas, P. Pelicon, , J. Strancar
This study shows that TiO2 nanotubes and MWCNTs induce different cancer-related changes in vitro, with TiO2 nanotubes disrupting microtubules and inducing binucleated cells, while MWCNTs activate the STING pathway.
bioRxiv · Jan 7, 2024 · PreprintCancer Biology