R. Heller

Binucleated cell formation and oncogene expression after particulate matter exposure is preceded by microtubule disruption, dysregulated cell cycle, prolonged mitosis, and septin binding

This study shows that TiO2 nanotubes and MWCNTs induce different cancer-related changes in vitro, with TiO2 nanotubes disrupting microtubules and inducing binucleated cells, while MWCNTs activate the STING pathway.

African bush pigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival

This study analyzes whole genomes of African bushpigs and Malagasy bushpigs, revealing recent divergence and gene flow, challenging species boundaries and linking their arrival in Madagascar to human migration.

Persistent gene flow suggests an absence of reproductive isolation in an African antelope speciation model

The paper sequenced waterbuck genomes to study speciation, finding historical gene flow across a Rift Valley barrier and no reproductive isolation.

Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

Joint identification of sex and sex-linked scaffolds in non-model organisms using low depth sequencing data

SATC identifies sample sex and sex-linked scaffolds from low-depth sequencing data using PCA and clustering without prior sex knowledge or related species data.

Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation

This study maps carboxymethyllysine (CML) modification sites on proteins in mouse and human cells, showing its impact on proteostasis and cell proliferation.

SARS-CoV-2 causes severe alveolar inflammation and barrier dysfunction

This study shows SARS-CoV-2 infects alveolar epithelial cells, causing inflammation and barrier dysfunction, while endothelial cells are damaged through cytokine release from infected epithelial cells.

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

Reproducibility and replicability of rodent phenotyping in preclinical studies

The paper discusses concerns about reproducibility and replicability in rodent phenotyping studies and emphasizes the need for improved data sharing and community efforts to address methodological issues.