The kidney protects against sepsis by producing systemic uromodulin
K. LaFavers, C. Hage, V. Gaur, R. Micanovic, T. Hato, S. Khan, S. Winfree, S. Doshi, R. Moorthi, H. Twigg, X.-R. Wu, P. Dagher, E. Srour, T. M. El-Achkar
This paper identifies uromodulin (THP) as a protective factor in sepsis, showing its role in enhancing mononuclear phagocyte function and reducing mortality in mice.
bioRxiv · Jan 8, 2021Immunology