BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Z. A. Bittner, X. Liu, S. Shankar, A. Tapia Abellan, H. Kalbacher, L. Andreeva, M. Mangan, P. Duewell, M. Lovotti, K. Bosch, S. Dickhoefer, A. Marcu, S. Stevanovic, F. Herster, M. W. Loeffler, , A. N. Weber
The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.
bioRxiv · Jun 25, 2020Immunology