Author

P. Fletcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:non-human primate· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1

Frequent Co-Authors

A. Marzi· 4 shared F. Feldmann· 3 shared C. S. Clancy· 2 shared G. Saturday· 2 shared K. L. O'Donnell· 2 shared P. W. Hanley· 2 shared A. Carmody· 1 shared A. N. Pinski· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

A. Marzi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A bivalent Adenovirus-Vectored Vaccine induces a measurable humoral response, but does not protect cynomolgus macaques against a lethal challenge with Sudan virus

S. van Tol, P. Fletcher, F. Feldmann, R. K. Mukesh, J. R. Port, S. Gallogly, J. E. Schulz, J. F. Roderick, R. Makinson, A. Carmody, L. Myers, J. Lovaglio, B. J. Smith, A. Okumura, C. Shaia, , N. van Doremalen

This study evaluates a bivalent Adenovirus-Vectored Vaccine in cynomolgus macaques against Sudan virus, finding it induces humoral responses but does not confer protection against lethal challenge.

bioRxiv · Oct 20, 2023Microbiology

VSV-based vaccine provides species-specific protection against Sudan virus challenge in macaques

A. Marzi, P. Fletcher, F. Feldmann, G. Saturday, P. W. Hanley, H. Feldmann

This study develops a VSV-based vaccine against Sudan virus and shows it protects macaques from lethal infection, highlighting the need for specific countermeasures against filoviruses.

bioRxiv · Oct 27, 2022 · PreprintMicrobiology

Rapid protection of nonhuman primates against Marburg virus disease using a single low-dose VSV-based vaccine

K. L. O'Donnell, F. Feldmann, B. Kaza, C. S. Clancy, P. W. Hanley, P. Fletcher, A. Marzi

A single low-dose VSV-based vaccine protects nonhuman primates from lethal Marburg virus disease regardless of administration timing.

bioRxiv · Sep 17, 2022Immunology

Pathogenic and transcriptomic differences of emerging SARS-CoV-2 variants in the Syrian golden hamster model

K. L. O'Donnell, A. N. Pinski, C. S. Clancy, T. Gourdine, K. Shifflett, P. Fletcher, I. Messaoudi, A. Marzi

This study compares the pathogenic and transcriptomic effects of SARS-CoV-2 variants B.1.1.7 and B.1.351 to the ancestral strain in Syrian golden hamsters, finding distinct humoral responses and transcriptional profiles.

bioRxiv · Jul 11, 2021Microbiology