Author

C. S. Clancy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Organism:non-human primate· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Marzi· 4 shared K. L. O'Donnell· 4 shared A. Sher· 3 shared K. D. Mayer-Barber· 3 shared K. L. Hilligan· 3 shared K. Shifflett· 3 shared N. L. Garza· 3 shared S. D. Oland· 3 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMicrobiology

A. Marzi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Pre-existing interferon gamma conditions the lung to mediate early control of SARS-CoV-2

K. L. Hilligan, S. Namasivayam, C. S. Clancy, P. J. Baker, S. I. Old, V. Peluf, E. P. Amaral, S. D. Oland, D. O'Mard, J. Laux, M. Cohen, N. L. Garza, B. Lafont, R. F. Johnson, C. G. Feng, , A. Sher

This study shows that pre-existing IFN-gamma responses from bacterial infection reduce SARS-CoV-2 viral loads in the lungs and protect against disease in mice.

bioRxiv · Jul 15, 2023 · PreprintImmunology

Helminth exposure protects against murine SARS-CoV-2 infection through macrophage dependent T cell activation

K. L. Hilligan, O. O. Oyesola, S. Namasivayam, N. Howard, C. S. Clancy, S. D. Oland, N. L. Garza, B. A. P. Lafont, R. F. Johnson, K. D. Mayer-Barber, A. Sher, P. Loke

This study shows that prior helminth infection reduces SARS-CoV-2 viral loads in mice by enhancing CD8+ T cell responses through macrophage-dependent mechanisms.

bioRxiv · Nov 9, 2022 · PreprintImmunology

Rapid protection of nonhuman primates against Marburg virus disease using a single low-dose VSV-based vaccine

K. L. O'Donnell, F. Feldmann, B. Kaza, C. S. Clancy, P. W. Hanley, P. Fletcher, A. Marzi

A single low-dose VSV-based vaccine protects nonhuman primates from lethal Marburg virus disease regardless of administration timing.

bioRxiv · Sep 17, 2022Immunology

Optimization of single dose VSV-based COVID-19 vaccination in hamsters

K. L. O'Donnell, C. S. Clancy, A. J. Griffin, K. Shifflett, T. Gourdine, T. Thomas, C. M. Long, W. Furuyama, A. Marzi

This study evaluates two VSV-based COVID-19 vaccines in hamsters, showing intranasal vaccination provides rapid protection against multiple SARS-CoV-2 variants.

bioRxiv · Sep 3, 2021Microbiology

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

K. L. Hilligan, S. Namasivayam, C. S. Clancy, D. O'Mard, S. D. Oland, S. J. Robertson, P. J. Baker, E. Castro, N. L. Garza, B. A. P. Lafont, R. Johnson, F. Ronchese, K. D. Mayer-Barber, S. M. Best, A. Sher

This study shows that intravenous BCG vaccination protects mice from lethal SARS-CoV-2 infection by altering pulmonary myeloid cell function and reducing immunopathology.

bioRxiv · Aug 30, 2021Immunology

Pathogenic and transcriptomic differences of emerging SARS-CoV-2 variants in the Syrian golden hamster model

K. L. O'Donnell, A. N. Pinski, C. S. Clancy, T. Gourdine, K. Shifflett, P. Fletcher, I. Messaoudi, A. Marzi

This study compares the pathogenic and transcriptomic effects of SARS-CoV-2 variants B.1.1.7 and B.1.351 to the ancestral strain in Syrian golden hamsters, finding distinct humoral responses and transcriptional profiles.

bioRxiv · Jul 11, 2021Microbiology

Rapid protection from COVID-19 in nonhuman primates vaccinated intramuscularly but not intranasally with a single dose of a recombinant vaccine

W. Furuyama, K. Shifflett, A. N. Pinksi, A. J. Griffin, F. Feldmann, A. Okumura, T. Gourdine, A. Jankeel, J. Lovaglio, P. W. Hanley, T. Thomas, C. S. Clancy, I. Messaoudi, K. L. O'Donnell, A. Marzi

A single-dose VSV-based vaccine protected nonhuman primates from COVID-19 within 10 days when administered intramuscularly but not intranasally.

bioRxiv · Jan 19, 2021 · PreprintMicrobiology