F. Feldmann

A bivalent Adenovirus-Vectored Vaccine induces a measurable humoral response, but does not protect cynomolgus macaques against a lethal challenge with Sudan virus

This study evaluates a bivalent Adenovirus-Vectored Vaccine in cynomolgus macaques against Sudan virus, finding it induces humoral responses but does not confer protection against lethal challenge.

Compartmentalized SARS-CoV-2 replication in upper versus lower respiratory tract after intranasal inoculation or aerosol exposure

This study compares SARS-CoV-2 replication in rhesus macaques after intranasal inoculation or aerosol exposure, finding differences in respiratory tract involvement.

VSV-based vaccine provides species-specific protection against Sudan virus challenge in macaques

This study develops a VSV-based vaccine against Sudan virus and shows it protects macaques from lethal infection, highlighting the need for specific countermeasures against filoviruses.

Nuclear translocation of spike mRNA and protein is a novel pathogenic feature of SARS-CoV-2.

This study identifies nuclear translocation of SARS-CoV-2 spike mRNA and protein as a novel pathogenic feature, linked to a unique NLS motif in the spike protein.

Rapid protection of nonhuman primates against Marburg virus disease using a single low-dose VSV-based vaccine

A single low-dose VSV-based vaccine protects nonhuman primates from lethal Marburg virus disease regardless of administration timing.

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

The combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model

MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern, including Omicron, in the Syrian hamster model.

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

This study compares immune dynamics in young and old rhesus macaques infected with SARS-CoV-2, finding age-related differences in post-acute immune responses but similar acute disease outcomes.

ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys

ChAdOx1 NiV vaccination protects African green monkeys from lethal Nipah virus infection, preventing disease signs and viral replication.

UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates

This study compares the respiratory replication and shedding of SARS-CoV-2 D614G and B.1.1.7 variants in African green monkeys, finding increased respiratory replication for B.1.1.7 but no disease enhancement.

A pigtailed macaque model for Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus

This paper establishes a pigtailed macaque model for KFDV and AHFV that replicates human disease symptoms and viral tropism.

Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques

This study compares the pathogenicity of SARS-CoV-2 variants B.1.1.7 and B.1.351 in rhesus macaques, finding differences in clinical outcomes and immune responses.

Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques

This study shows that T cell depletion in rhesus macaques does not cause severe SARS-CoV-2 disease but delays viral clearance, and T cells are not essential for immunological memory or protection against re-infection.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine protects against SARS-CoV-2 infection in rhesus macaques by inducing neutralizing antibodies and T cell responses.

Rapid protection from COVID-19 in nonhuman primates vaccinated intramuscularly but not intranasally with a single dose of a recombinant vaccine

A single-dose VSV-based vaccine protected nonhuman primates from COVID-19 within 10 days when administered intramuscularly but not intranasally.

Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD

This study shows that goblet cells in COPD patients are more susceptible to SARS-CoV-2 infection due to higher ACE2 and TMPRSS2 expression, leading to increased viral replication.

Immunocompetent Mouse Model for Crimean-Congo Hemorrhagic Fever Virus

This paper develops an immunocompetent mouse model for CCHFV that replicates human disease severity, enabling better study of host-viral interactions.

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

SARS-CoV-2 infection dynamics in lungs of African green monkeys

This study examines SARS-CoV-2 infection dynamics in African green monkeys, showing viral replication in the lower respiratory tract and macrophage involvement in inflammation.

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

A single dose of ChAdOx1 MERS provides broad protective immunity against a variety of MERS-CoV strains

A single dose of ChAdOx1 MERS vaccine protects rhesus macaques and mice against MERS-CoV infection and multiple strains.

Respiratory disease and virus shedding in rhesus macaques inoculated with SARS-CoV-2

This study shows that SARS-CoV-2 causes respiratory disease in rhesus macaques with symptoms similar to human cases, including prolonged viral shedding.