ImmunologybioRxiv
Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ after myocardial infarction
L. Alonso-Herranz, A. Sahun-Espanol, P. Gonzalo…·M. Ricote
This study shows that macrophage MT1-MMP promotes EndMT in cardiac endothelial cells after MI, contributing to fibrosis and adverse remodeling, and identifies it as a potential therapeutic target.
DOI 10.7554/elife.57920