Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ after myocardial infarction
L. Alonso-Herranz, A. Sahun-Espanol, P. Gonzalo, P. Gkontra, V. Nunez, M. Cedenilla, M. Villalba-Orero, J. Inserte, C. Clemente, D. Garcia-Dorado, A. G. Arroyo, M. Ricote
This study shows that macrophage MT1-MMP promotes EndMT in cardiac endothelial cells after MI, contributing to fibrosis and adverse remodeling, and identifies it as a potential therapeutic target.
bioRxiv · Aug 7, 2020Immunology