Long non-coding RNA GAS5 acts as proliferation brakes in CD133+ cells responsible for tumor recurrence
N. S. Sharma, P. Gnamlin, B. C. Durden, V. K. Gupta, K. Kesh, V. Garrido, R. Hadad, V. Dudeja, A. Saluja, S. Banerjee
This study shows GAS5 regulates quiescence and growth arrest in CD133+ cells, which drive tumor recurrence in pancreatic cancer by inhibiting cell cycle progression and altering metabolic pathways.
bioRxiv · Jun 13, 2019Cancer Biology