Author

A. Saluja

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2

Frequent Co-Authors

V. K. Gupta· 6 shared K. Kesh· 5 shared S. Banerjee· 5 shared N. S. Sharma· 4 shared R. Hadad· 3 shared V. Dudeja· 3 shared V. T. Garrido· 3 shared B. C. Durden· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersCancer Biology

V. K. Gupta

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The Effect of Minnelide against SARS-CoV-2 in a Murine Model

M. C. Caballero Van Dyke, H. L. Mead, M. Bryant, K. L. Laux, D. R. Kollath, V. K. Coyne, K. J. Miller, N. E. Stone, S. A. Jaramillo, P. Keim, C. Milikowski, V. K. Gupta, S. M. Vickers, A. Saluja, M. R. Velagapudi, B. M. Barker

This study evaluates Minnelide's efficacy in treating SARS-CoV-2 infection in mice, showing reduced viral load, improved survival, and decreased inflammation.

bioRxiv · May 5, 2021 · PreprintMicrobiology

Stroma secreted IL6 selects for stem-like population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways

K. Kesh, V. T. Garrido, A. Doesch, B. Durden, V. K. Gupta, N. S. Sharma, M. Lyle, N. Nagathihalli, N. Merchant, A. Saluja, S. Banerjee

This study shows that stromal IL6 promotes stem-like cells and metabolic reprogramming in pancreatic tumors, creating an immune-evasive microenvironment that can be targeted to improve checkpoint inhibitor therapy.

Cell Death & Disease · Nov 11, 2020Peer-reviewedCancer Biology

Hypoxia driven oncometabolite L-2HG maintains "stemness"-differentiation balance and facilitates immune suppression in pancreatic cancer

V. K. Gupta, N. S. Sharma, B. Durden, V. T. Garrido, K. Kesh, D. Edwards, D. Wang, C. Myers, S. K. Bhattacharya, A. Saluja, P. K. Singh, S. Banerjee

This study shows hypoxia drives L-2HG production in pancreatic tumors, maintaining stemness-differentiation balance and promoting immune suppression, with LDH inhibition reversing these effects.

bioRxiv · May 8, 2020Cancer Biology

Targeting tumor intrinsic metabolic node in pancreatic cancer causes tumor regression, remodels extracellular matrix and sensitizes to anti-PD1 therapy.

N. S. Sharma, V. K. Gupta, V. T. Garrido, R. Hadad, B. C. Durden, K. Kesh, B. Giri, A. Ferrantella, V. Dudeja, A. Saluja, S. Banerjee

This study shows that targeting the HBP metabolic node in pancreatic cancer with DON reduces tumor growth, remodels the ECM, and enhances response to anti-PD1 therapy.

bioRxiv · Sep 18, 2019Cancer Biology

Long non-coding RNA GAS5 acts as proliferation brakes in CD133+ cells responsible for tumor recurrence

N. S. Sharma, P. Gnamlin, B. C. Durden, V. K. Gupta, K. Kesh, V. Garrido, R. Hadad, V. Dudeja, A. Saluja, S. Banerjee

This study shows GAS5 regulates quiescence and growth arrest in CD133+ cells, which drive tumor recurrence in pancreatic cancer by inhibiting cell cycle progression and altering metabolic pathways.

bioRxiv · Jun 13, 2019Cancer Biology

O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancer

N. Sharma, V. K. Gupta, P. Dauer, K. Kesh, R. Hadad, B. Giri, A. Chandra, V. Dudeja, C. Slawson, S. Banerjee, S. M. Vickers, A. Saluja, S. Banerjee

This study shows that O-GlcNAc modification of Sox2 stabilizes the protein and enhances self-renewal in pancreatic cancer, with targeting OGT reducing tumor burden.

bioRxiv · Jun 12, 2018Cancer Biology