B cells are addicted to immunoglobulin production in the ER
M. Caganova, H. Taskiran, Y. Zong, A. Zach, E. Kabrani, K. Schmidt, P. Goffing, J. Jellusova, K. Rajewsky
The paper shows that B cells rely on ER-resident immunoglobulin heavy chains for ER homeostasis and mitochondrial function, independent of BCR signaling.
bioRxiv · Mar 11, 2022 · PreprintImmunology