Vitamin B5 Metabolism is Essential for Vacuolar and Mitochondrial Integrity and Xenobiotic Detoxification in Fungi
J.-Y. Choi, S. Gihaz, M. Munshi, P. Singh, P. Vydyam, P. Hamel, E. M. Adams, K. Fuller, C. Ben Mamoun
This study shows that disrupting the PCA pathway in fungi affects vacuolar integrity, drug detoxification, and susceptibility to antifungal drugs, supporting its potential as a therapeutic target.
bioRxiv · Dec 10, 2023 · PreprintMicrobiology