S. Joost

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

RECIFS: a centralized geo-environmental database for coral reef research and conservation

RECIFS provides an accessible database of environmental data for coral reef research, enabling analysis of environmental drivers and conservation strategies.

Multiple adaptive solutions to face climatic constraints: novel insights in the debate over the role of convergence in local adaptation

The paper compares adaptive trajectories in sheep and goats to explore genomic convergence in local adaptation, finding few shared adaptive genes and suggesting diverse mechanisms.

Worldwide analysis of reef surveys sorts coral taxa by associations with recent and past heat stress

The paper analyzes global reef survey data to identify how different coral taxa respond to recent and past heat stress, finding taxa-specific patterns of coral cover association with thermal anomalies.

Evaluating urban greening scenarios for urban heat mitigation: a spatially-explicit approach

This paper evaluates urban greening scenarios for heat mitigation using a spatially-explicit approach and the InVEST model in Lausanne.

Coral cover surveys corroborate predictions on reef adaptive potential to thermal stress

The paper uses seascape genomics to predict coral reef adaptation to thermal stress and finds that reefs with higher predicted adaptation and connectivity show less coral cover decline after heat stress.

Nested species distribution models of Chlamydiales in tick host Ixodes ricinus in Switzerland

The paper models the spatial distribution of ticks and Chlamydiales bacteria in Switzerland from 2009 to 2018, identifying environmental factors and showing an expansion of suitable habitats.

Seascape genomics reveals candidate molecular targets of heat stress adaptation in three coral species

This study uses seascape genomics to identify molecular targets of heat stress adaptation in three coral species, finding heat-associated SNPs near genes involved in DNA repair, protein folding, and stress response pathways.

Big dairy data to disentangle the effect of geo-environmental, physiological and morphological factors on milk production of mountain-pastured Braunvieh cows

This study analyzes milk production data from mountain-pastured Braunvieh cows to assess the impact of environmental, physiological, and morphological factors on productivity during transhumance.

Seascape genomics as a new tool to empower coral reef conservation strategies: an example on north-western Pacific Acropora digitifera.

This paper applies seascape genomics and connectivity analysis to identify adaptive genomic regions in Acropora digitifera, providing a framework for coral reef conservation.

The molecular anatomy of mouse skin during hair growth and rest

The paper creates a comprehensive single-cell transcriptome atlas of mouse skin during hair growth and rest, identifying key cell populations and their molecular and spatial organization.

Sampling strategy optimization to increase statistical power in landscape genomics: a simulation-based approach

This study optimizes sampling strategies for landscape genomics by simulating datasets under different scenarios to improve statistical power and reduce false discoveries.

Combining landscape genomics and ecological modelling to investigate local adaptation of indigenous Ugandan cattle to East Coast fever

The paper investigates genetic bases of East Coast fever tolerance in Ugandan cattle using landscape genomics and identifies candidate adaptive loci associated with tick resistance and infection tolerance.

Simple rules for an efficient use of Geographic Information Systems in molecular ecology

This paper provides guidance on using open-source GIS tools for molecular ecology, focusing on data management, software, and spatial analysis techniques.